Evaluate the inhibition of cytochrome P450 1A1 for enhancing breast cancer chemotherapy with a turn-on fluorescent probe

The incidence rate of breast cancer ranks first in women malignant tumors worldwide, accompanied by a high mortality. early diagnosis and therapy are important way to reduce the mortality clinical practice. There urgent needs for anti-tumor strategies with clear evidence reliable efficacy. Because cytochrome P450 1A1 (CYP1A1) is commonly expressed has excellent ability metabolize xenobiotics, researchers interested studying vital function CYP1A1 cancer. Herein, we report BCy-CYP fluorescent probe imaging cells vivo. This outstanding selectivity sensitivity detection over other biomolecules. Our results reveal that intracellular level increase MCF-7 MDA-MB-231 cells, inhibition carnosol efficiently induce apoptosis two kinds cells. Thus, plays crucial role synergistic effect chemotherapy drug better than alone tumor-bearing mice. may be new biomarker diagnosis.